dysphoria

/dɪsˈfɔriə/
noun
  1. A state of deep unease, dissatisfaction, or emotional discomfort.
    • Many people experience dysphoria after major life changes like moving to a new city.
    • She felt a sense of dysphoria that she couldn't explain, even though nothing was wrong.
    • The patient's dysphoria lifted after starting a new treatment plan.
Antonyms
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