embitter

/ɪmˈbɪtər/
verb
  1. To make someone feel angry, unhappy, or resentful over time, usually because of unfair treatment or disappointment.
    • Years of rejection embittered the artist, and he stopped trusting critics.
    • Constant teasing in school can embitter a child and affect their friendships.
    • The unfair layoff embittered her against the company she had served for decades.
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