frameshift
/ˈfreɪmˌʃɪft/
noun
- A genetic mutation caused by inserting or deleting nucleotides in a DNA sequence, which changes the reading frame and alters the resulting protein.
- The frameshift in the gene led to a nonfunctional enzyme.
- Scientists studied the frameshift to understand how the disease developed.
- A frameshift mutation can cause a completely different protein to be made.