hypomorphic
/ˌhaɪpoʊˈmɔrfɪk/
adjective
- Describing a gene or genetic mutation that results in a partial loss of function, producing a weaker or less active version of a protein.
- The hypomorphic mutation in the lab mice caused only mild symptoms compared to the complete gene knockout.
- A hypomorphic variant of the gene might still produce some functional enzyme, just not enough for normal health.
- Scientists studied a hypomorphic allele to understand how reduced protein activity affects development.